Astitva - Ek Prem Kahani is about the unconventional story of Dr. Simran Mathur (Niki Aneja Walia), a gynaecologist who marries a boy Abhimanyu (Varun Badola), ten years younger to her. And thus unfolds a series of drama and melodrama as the parents of the couple refuse to accept them. Will Simran and Abhimanyu's love rise above the taunts and jeers thrown at them by everyone around? Or will their love crumble and eventually succumb to familial and societal pressure?